• Well, imagine if that change in structure could be switched on and off by addition of a phosphorous; and in fact it can in many proteins.

    那么,想象一下,只需引入磷酸基团,就能导致蛋白质的结构发生变化,事实上很多蛋白质就是如此

    耶鲁公开课 - 生物医学工程探索课程节选

  • There are 100 of these molecules, when a receptor gets activated a kinase activity gets activated, the kinase acts on the protein, the protein gets switched on, something new starts to happen inside the cell.

    有一百个这样的分子,当受体被激活,激酶被激活后,激酶作用于蛋白,使蛋白活化,细胞中就会发生一些新变化

    耶鲁公开课 - 生物医学工程探索课程节选

  • How--how much of a health improvement that represents depends in part on what the restaurant switched the Trans fat for.

    人体健康得到多少的改善,部分取决于餐馆把反式脂肪换成了什么

    耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

  • The cognitive structures are still there, but the on-off switch is switched to off.

    认知结构仍然存在,只是开关还没有被开启。

    耶鲁公开课 - 死亡课程节选

  • Some proteins can be switched from an 'off' position where they don't do anything to an 'on' position where they now do something by only a chemical reaction like this where a phosphorous is added.

    一些蛋白质可以从关闭状态的,无所作为,到成为开启状态后,执行某种功能,中间只发生了一个引入磷酸基的化学反应

    耶鲁公开课 - 生物医学工程探索课程节选

  • If that protein is an enzyme then you've and you've switched it from an 'off' position where it's not catalyzing a reaction to an 'on' position where it is, you've changed the biochemical state of the cell, you've changed the chemical reactions that can occur within the cell, and you've changed its behavior.

    如果这种蛋白是一种酶的话,你就能够将酶从无催化作用的静息态,激活至能催化反应的激活态,你改变了细胞的生化状态,也改变了细胞内发生的化学反应,改变了细胞的行为

    耶鲁公开课 - 生物医学工程探索课程节选

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