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But what we're trying to do now is identify the key influencers in those merchant areas and make them distribution points.
但我们现在努力要做的是,在商界确定,最重要的影响因素,让他们变为非配点。
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So it's always that classic match-up of just like opposites, but it's great to watch and everything.
所以这又是一个经典的两极绝配，很好看的一部剧。
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So I mentioned, however, that in terms of de Broglie's work. T his was Nobel Prize worthy, absolutely, but it was also his PhD thesis.
然而，我提到的是德布罗意的工作，这个工作是绝对是,配得上诺贝尔奖的，而且它也是德布罗意的博士论文。
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Let your repentance salt my shoe leather," I said presently, " and then, as I lately sheathed my blade of anger, so sheath you my blade of love."
你的悔意只配擦我的皮鞋，我当即就说“,方才我收起愤怒之剑时，也收起了对你的爱情之剑“
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They prevent the ligand from reaching its natural receptor, and so that antagonizes or inhibits the function of the natural ligand.
它们能够阻止配体与受体的结合,这样就拮抗或者说是抑制了配体的功能
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This is called a dative bond.
这种化学键称为配位键。
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Eleven dollars per part at 12.5 million cars and trucks came to a total cost of $137 million to improve the safety.
给1250万辆轿车和卡车配上11美元的隔板,提高安全性，共需花费一亿三千七百万美元。
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I'm still trying to work out a role for you so hang on for one sec.
我还在想给你配个什么角色,先等一会儿吧。
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But if you've got the Germans in Ostende eating moules frites, eating mussels with French fries, and you've already got the french there, this is unthinkable.
但如果德国人在奥斯坦德吃着淡菜炸薯条,也就是薯条配淡菜,和法国人一同窥伺英伦,这是难以想象的
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So it has a kind of antecedent-consequent phrase structure with the chord.
这里像是一个前后分句的结构，配上和弦。
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Okay, Chili's Chocolate Chip Paradise Pie with ice cream.
红辣椒餐厅的巧克力屑天堂派配冰激凌
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That ligand was one for which the cell had a receptor that further encouraged it to produce more of the ligand.
对于带有对应受体的细胞来说,这种配体能够刺激细胞产生更多的配体
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So this can tell you why it's so happy with only having six electrons around it.
这里它不倾向于,全满的八配位。
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Sometimes receptors, when they interact with ligands, create changes in what proteins are actually being produced by the cell.
有时受体与配体结合后,带来的变化实际是,决定细胞开始合成何种蛋白质
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What insulin is doing inside your body is acting as a ligand for insulin receptors which stimulate certain kinds of cellular responses.
胰岛素在体内的功能就是作为,胰岛素受体的配体,刺激产生某种细胞效应
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In the case of a ligand-receptor, a chemical signal in the form of a concentration of ligand gets converted into a biochemical signal.
在配体-受体系统中,配体浓度这种化学信号,转化为生化信号
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Let's try something like four, which is what? Methane.
试试配位原子有4个的，那是什么东西，甲烷。
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Sometimes you can design drugs that act like a natural ligand without being the natural ligand.
有时你能设计具有天然配体功能的药物,但它不一定和天然配体相同
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The rest of these examples refer to receptors as I've been describing them and ligands that are soluble and can move around the body.
我接下来要讲的有关受体,以及能游走于体内各处可溶性的配体
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When these vesicles dump their contents into the synaptic cleft, the concentration of these ligands rise.
当这些小泡将其内含物释放入突触间隙,这些配体的浓度即增加
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This would an example of a substance that inhibits the action of a natural ligand and they can inhibit in a variety of ways.
这类物质能够以多种方式,抑制天然配体的作用
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If a ligand comes and interacts with a receptor, it opens up; In the presence of this ligand, if the ligand goes away, it closes.
如果配体与受体相互作用,在配体存在的情况下通道打开,如果配体脱离,通道就关闭
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Today let's think about it more generally as ligands and receptors.
今天我们讲讲普遍意义上的配体和受体
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Just curious; before the ligand perimeter where are they stored?
只是好奇,配体释放到周围前储存在哪
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Well, then you could imagine a cycle here where activation of the receptor is leading to production of more ligand, is leading to activation of the receptor and production of a ligand.
那么,你就能画出一个循环图,激活受体能导致,更多配体的生成,这些配体又会刺激受体生成更多配体
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It refers to usually 'receptors' that are fixed in a cell, on a cell membrane, and 'ligands' which are dispersed throughout the body and free to diffuse around, and occasionally will find the cell.
受体这个词通常代表了,固定于细胞表面的分子,而配体分散于体内各处,能够自由扩散,它们偶尔会与细胞邂逅
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The cell that's producing the signal produces enough of the molecule so that it enters the bloodstream, it circulates throughout your body, eventually it reaches a cell at a great distance, which has a receptor for that ligand and the signal gets received.
发出信号的细胞产生信号分子,数量十分充足 能够进入到血液中,信号随着血液流遍全身,最终到达较远处的细胞,在这些细胞上有与配体配对的受体,信号被细胞接收
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There's not actually chemical covalent bonds that are formed but it's a non-covalent interaction, usually dominated by hydrogen bonding.
所以配体和受体之间不生成共价键,这是一种非共价化合反应,它们通常以氢键相联
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What are - this understanding of receptor-ligand interactions has been really the biological basis of much of the pharmaceutical industry.
受体-配体相互作用理论,现在已经成为很多,制药工业的生物学基础
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If it was sound that was being received that might be beating of a drum, for example, that sound gets transduced.
如果将配体看作是,有待接受的敲鼓声,声音信号得到了转换
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