You must be disappointed at losing the chance.
失去这次机会，你肯定很失望吧。
I told them that they would be disappointed at the news.
我告诉他们，听到这个消息，他们会失望的。
At this point, you may be a bit disappointed.
到了这里，您可能觉得有一点失望。
He must be very disappointed with [at, about] your exam results.
他对你的考试成绩一定非常失望。
I fear she would be very disappointed looking at the world today.
观看当今世界，恐怕她会很失望的。
I fear she would be very disappointed looking at the world today.
观看当今世界，恐怕她会很失望的。
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