In spite of everything and against tremendous odds, they succeeded.
尽管经历了巨大的艰难，但最后还是成功了。
In spite of everything I still believe that people are really good at heart.
不管发生什么事，我始终相信人们内心是善良的。
In spite of one or two minor mishaps everything was going swimmingly.
尽管遇到了一两件小小的不幸，一切都进行得很顺利。
In spite of one or two minor mishaps everything was going swimmingly.
尽管遇到了一两件小小的不幸，一切都进行得很顺利。
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