Methods: Whole-cell patch clamp technique was used to determine sodium channel cur rent.
方法：采用全细胞膜片钳技术，记录钠通道电流。
Garlicin blocks sodium channel in its inactive state in a dose- and voltage-dependent manner.
其对失活曲线有明显影响，提示大蒜素主要作用于钠通道的失活态。
Methods PCR method was applied to detect the KDR mutation of the target site (sodium channel) gene.
方法采用聚合酶链反应(PCR)方法，用自行设计的特异引物，对昆虫的钠离子通道基因进行扩增。
This paper reviews the current progress of the relationship between Kdr - type resistance and sodium channel.
综述了击倒抗性与钠离子通道关系的研究进展。
Biaryl substituted pyrazole compounds are sodium channel blockers useful for the treatment of pain and other conditions.
联芳基取代吡唑化合物为钠通道阻滞剂，用于治疗疼痛和其它病症。
Biaryl substituted pyridine, pyrimidine and pyrazine compounds are sodium channel blockers useful for the treatment of pain.
联芳基取代的吡啶、嘧啶和吡嗪化合物为用于治疗疼痛的钠通道阻滞剂。
The whole-cell patch-clamp recording technique was used to record the change of sodium channel current influenced by carvedilol.
方法用急性酶解法获得单个大鼠心室肌细胞，标准的全细胞膜片钳技术记录钠通道电流。
Objective: to investigate the effects of blood resin on voltage gated sodium channel current in freshly isolated rat DRG neurons.
目的：研究血竭对大鼠背根神经节细胞电压门控性钠通道电流的影响。
So, what happens, this is another view of a sodium channel, so this is actually looking a little bit more at the protein structure.
那么，这里发生了什么，这是钠离子通道的另一张图片，在这种蛋白质结构中，它看起来更复杂一点。
So, what happens, this is another view of a sodium channel, so this is actually looking a little bit more at the protein structure .
那么，这里发生了什么，这是钠离子通道的另一张图片，在这种蛋白质结构中，它看起来更复杂一点。
Conclusion With the use of DNP, lidocaine can achieve the effect of brain protection through inhibiting the voltage-dependent sodium channel.
结论在DNP作用下，利多卡因可通过抑制电压依赖性钠通道起到脑保护作用。
Objective To investigate whether the mutations in the cardiac sodium channel gene SCN 5 a can cause the idiopathic ventricular fibrillation (IVF).
目的研究心脏钠离子通道基因scn5A的突变是否能够引起自发性心室纤颤(ivf)，以帮助IVF的基因诊断和合理治疗。
Tetrodotoxin (TTX) is a potent sodium channel blocker. It can affect the generation of action potentials of cell membranes by blocking sodium channel.
河豚毒素为强效钠通道阻滞剂，它可通过阻断钠通道而影响细胞膜动作电位的产生。
These included mutations in the sodium channel gene SCN5A, previously associated with LQTS and other unstable heart rhythm conditions and sudden death.
这其中包括钠通道基因scn5a的突变，该基因以前发现与LQTS、其他不稳定心律失常以及猝死相关。
However, when that gate is opened, the sodium channel is now going to be incredibly selective and only let through sodium ions and no other type of ion.
但是，当闸门打开的时候，钠离子通道，将会有极高的选择性，不允许除钠离子以外的任何其它离子通过。
Neuropathic pain is an intractable chronic pain. The efficacy of sodium channel inhibitor for treating these pain has been researched during the past decade.
神经病理性疼痛是慢性疼痛中的研究热点，其产生机制复杂，治疗方法虽多，但尚未有适用于各种类型神经病理性疼痛的疗法。
Conclusions the IVF with RBBB and st segment elevation is a distinct syndrome, and the mutations in the cardiac sodium channel gene SCN 5 a are associated with IVF.
结论我们的工作显示了伴有rbbb和ST段抬高的IVF是一种明显的综合征，并且心脏钠通道基因scn5A与IVF的发生密切相关。
Jingzhaotoxin-I(JZTX-I), a 33-residue polypeptide with three disulfide bonds, was a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivation.
敬钊毒素-I（JZTX-I）是一种能够抑制心肌钠通道失活的新型蜘蛛神经毒素，该文结合高效液相色谱与色氨酸荧光测定技术研究了JZTX-I的磷脂膜结合活性。
In this thesis, phenomena and mechanism of genetic diseases caused by many channel proteins, such as aquatic, calcium, sodium channels, potassium channel proteins, are...
本文从水通道蛋白，钙通道，钠通道，钾通道等多种通道蛋白引起的遗传病的现象以及机理做较深入的阐述。
ChinaABSTRACT: Objective To explore the effect of ranolazine on the fast sodium channel current (ina) in rabbit atrial myocytes and the existence of use-dependent blockade.
目的研究雷诺嗪对兔心房肌细胞快钠电流的影响及其是否存在使用依赖性阻滞作用。
To observe the effect of Garlicin on sodium channel in isolated ventricular cell of rats, to find out the mechanism of antiarrhythmia of Garlicin on the ionic channel level.
目的 研究大蒜素对豚鼠心室肌细胞膜快钠通道的影响，探讨大蒜素在离子通道水平的抗心律失常作用机制。
Method: the whole cell patch clamp recording technique was used in this study. Results: blood resin suppressed amplitude of the sodium channel currents in a dose dependent way.
方法：采用全细胞膜片钳记录法，在新鲜分离的大鼠背根神经节细胞上观察血竭对钠通道电流幅值的影响。
The inhibition effect was irreversible at high dosage. Conclusion: blood resin inhibits the voltage gated sodium channel currents, which may well provide some analgesic effects.
结果：血竭剂量依赖地抑制单个DRG细胞电压门控性钠通道电流，高剂量的血竭抑制作用不可逆。
Objective:To study the effect of scorpion polypeptide purified from Buthus martensi Karsch(BmK) venom on membrane potential of PC12 cells and its correlation with sodium channel.
目的：研究东亚钳蝎毒素多肽对PC12细胞膜电位的影响及其与钠通道的关系。
Most local anaesthetics used clinically are relatively hydrophobic molecules that gain access to their blocking site on the sodium channel by diffusing into or through the cell membrane.
大多数应用于临床的局麻药物都是相对疏水性的分子，可弥散通过细胞膜，作用于阻滞部位的钠通道。
We show that sodium channels with the missense mutation recover from inactivation more rapidly than normal and that the frameshift mutation causes the sodium channel to be non-functional.
电生理研究显示含有错义突变的钠离子通道比正常通道从静止中恢复的更快，而读码突变使钠离子通道失去功能。
Studies of these results show that the sodium channel blockade has common structural features and way of action when interact with the receptor, thus leading to identical biological effect.
这表明钠离子通道阻断剂在与受体相互作用时具有共同的结构特征和作用方式，同时也为探讨受体结构提供了有价值的信息。
In this thesis, phenomena and mechanism of genetic diseases caused by many channel proteins, such as aquatic, calcium, sodium channels, potassium channel proteins, are discussed elaborately.
本文从水通道蛋白，钙通道，钠通道，钾通道等多种通道蛋白引起的遗传病的现象以及机理做较深入的阐述。
Comparative genomics shows that sodium channel and pump proteins evolved just before multicellular animals arose, implying that control of electrolyte balancing was a crucial event in life's history.
比较基因学告诉我们钠通道和泵蛋白的演变进化是在多细胞动物崛起之前就发生了的。同时这也暗示说明点解平衡的控制在生命历程中是一个起着决定性作用的过程。
An ion channel is a molecule that allows the passage of electrically charged atoms of sodium, potassium, calcium and so on through the outer membrane of a cell.
离子通道是一种分子，它允许钠、钾、钙等离子经由它通过细胞外膜。
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