The experimental process on synthesis of roxithromycin was studied by using erythromycin oxime and MEMC as raw material under the catalytic action of anhydrous sodium carbonate.
研究了以无水碳酸钠为催化剂，红霉素肟与甲氧基乙氧基氯甲醚(MEMC)为原料，一步合成罗红霉素的实验过程。
The first part: synthesis and in vitro activity of 3-keto-9-o-substituted oxime derivatives of 6-o-methyl erythromycin a.
第一部分：3 -酮基- 6 - O -甲基红霉素- 9 -取代肟基衍生物的合成与体外抗菌活性。
The E configuration of erythromycin oxime was found to transfer easily to the Z configuration to equilibrium under the condition of alkalescence.
碱性条件下红霉素肟容易由E构型转化为Z构型从而达到平衡。
The present invention is new technological process of preparing erythromycin A-9-oxime compound as one intermediate of macrolide antibiotics.
本发明提供了一种制备大环内酯类抗生素衍生物的一种中间体红霉素A - 9 -肟化合物的制备新工艺。
The present invention is new technological process of preparing erythromycin A-9-oxime compound as one intermediate of macrolide antibiotics.
本发明提供了一种制备大环内酯类抗生素衍生物的一种中间体红霉素A - 9 -肟化合物的制备新工艺。
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