发现一种可以穿越血脑屏障的药物是阿尔茨海默氏病和其他脑部神经疾病药物研制中的障碍。
Finding a drug that can cross the blood-brain barrier is the bane of drug development for Alzheimer's disease and other neurological disorders of the brain.
尽管胆固醇整天被认为是个对人体有害的物质，但它却是脑的重要成分，是通过血脑屏障的常客。
That made the aminothiazoles look more like cholesterol—which despite its malign everyday reputation is an important component of brains and routinely crosses the blood-brain barrier.
目的：氟桂利嗪是通过血脑屏障的细胞钙超载阻滞剂。
AIM: Flunarizine is a blocker for calcium overload of cells, which could pass blood brain barrier.
血脑屏障通透性增高是造成血管源性脑水肿和炎症反应等病理学变化的主要环节。
The increase of blood-brain barrier (BBB) permeability is a key link in causing the pathological changes in vasogenic brain edema and inflammatory reaction.
人体的循环系统里有一些有害的化学物质，血脑屏障是一道防御这些有害物质的天然屏障，但这道屏障同时也将治疗药物隔于脑外。
This barrier is a natural defence against potentially harmful chemicals floating around the body but has also stopped useful drugs reaching the brain as well.
活性氧簇(ROS)是神经系统脱髓鞘及血脑屏障破坏的媒介。
Reactive oxygen species (ROS) are mediators of demyelination and disruption of the blood-brain barrier (BBB).
同时他还说：“这个研究结果强调了这样一个事实——血脑屏障的通透性改变是发生象实验性变应性脑脊髓炎(一种多发性硬化病的动物模型)这类中枢神经系统感染性疾病的重要因素。”
"This puts an emphasis on the fact that blood brain permeability changes are an important aspect of the development of a CNS inflammatory disease like EAE, an animal model of MS," he says.
她补充说：“利用腺苷受体看来是越过血脑屏障的更通用方式。”
"Utilizing adenosine receptors seems to be a more generalized gateway across the barrier," she added.
寻找有效的给药途径，避开血脑屏障的阻断，将药物直接运送到中枢神经系统一直是神经科学家面临的挑战。
Finding an effective approach to carry drugs, keeping off BBB and taking drugs to NCS directly puzzled neurologists all long time.
但血脑屏障的存在却使外源性基因难以进入脑内，是中枢神经系统转基因治疗的主要障碍。
But it is difficult for exogenous gene to enter brain because of the presence of the blood-brain barrier (BBB). This is the main obstacle for gene transfer therapy in central nervous system.
瘤内放射治疗是将放射性药物直接置于肿瘤残腔内，直接作用于胶质瘤细胞，此法能避开血脑屏障同时也能提高局部药物浓度。
Radiation therapy for tumors is that radioactive substances is directly placed in the tumor residual cavity, to avoid the blood-brain barrier and improve local drug concentration.
血脑屏障是一个细胞系统，它能调节大脑和血液间的物质交换。
The blood-brain barrier is a system of cells that regulates the exchange of substances between the brain and the blood.
颅内压升高、脑血管自身调节功能失常和血脑屏障损害，是急性重症颅脑损伤的三大重要病理生理学特点。
Intracranial hypertension, impaired cerebral vascular auto-regulation and disrupted brain blood barrier are the three major pathophysiological characteristics in patients with severe brain injury.
颅内压升高、脑血管自身调节功能失常和血脑屏障损害，是急性重症颅脑损伤的三大重要病理生理学特点。
Intracranial hypertension, impaired cerebral vascular auto-regulation and disrupted brain blood barrier are the three major pathophysiological characteristics in patients with severe brain injury.
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