目的：对更昔洛韦的合成工艺进行改进。
移植前采用更昔洛韦预防CM V感染。
Ganciclovir was used to prevent CMV infection before the transplantation.
目的观察更昔洛韦治疗小儿病毒性脑炎的临床疗效。
Objective To observe the clinical therapeutic effects of Ganciclovir on the children with virus encephalitis.
本发明还涉及该注射用更昔洛韦冻干制剂的制备方法。
The invention also relates to a preparation method of the Ganciclovir freeze-dry preparation for injection.
巨细胞病毒感染可使用药物治疗，如更昔洛韦，缬更昔洛韦和膦甲酸。
CMV infection may be treated with drugs such as ganciclovir, valganciclovir and forscarnet.
目的探讨更昔洛韦在巨细胞病毒肝炎治疗中的方法及疗效。
Objective To explore more acyclovir hepatitis treatments in the methods and CMV curative.
结论：更昔洛韦治疗儿童EB病毒性脑炎效果明显而安全。
Conclusion: Ganciclovir is the most effective and safe in treatment of children with viral encephalitis caused by EBV.
结论该方法简便、可行，可用于检测注射用更昔洛韦的含量。
Conclusion The proposed method is simple, conventinent and is suitable for the quality control of Ganciclovir for injection.
目的观察更昔洛韦治疗儿童传染性单核细胞增多症的临床疗效。
Objective To observe the clinical curative effect of ganciclovir for the treatment of children with infectious mononucleosis .
合并滤液和洗涤液浓缩并冻干以分离更昔洛韦L -缬氨酸酯。
The combined filtrates from filtration and the washings are concentrated and lyophilized to isolate ganciclovir L-valine ester.
研究更昔洛韦配伍西咪替丁治疗婴幼儿轮状病毒性肠炎的疗效。
To study on the the effect of ganciclovir combined with cimetidine on infants with rotavirus enteritis.
目的：探讨更昔洛韦对转染TK基因的骨髓瘤细胞生长的抑制作用。
Objective: To illustrate the effect on myeloma cells with TK gene by GCV.
目的：探讨更昔洛韦与西咪替丁联合治疗婴幼儿轮状病毒肠炎的效果。
Objective: To explore the effect of ganciclovir and cimetidine therapy on infants with rotavirus enteritis.
第二步：2-氨基和一个脂链羟基被保护的更昔洛韦要脱除氨基保护。
Step II: Ganciclovir with a protected 2-amino group and one aliphatic hydroxy group protected is subjected to de-protection of the amino group.
近期发现：先期预防性应用缬更昔洛韦在对巨细胞病毒的预防是有效的。
Recent findings: Valganciclovir has proved effective in cytomegalovirus prevention for prophylactic and preemptive therapy.
结论更昔洛韦联合炎琥宁对传染性单核细胞增多症治疗较单剂更昔洛韦有效。
The treatment group got a obvious decrease in the ALP. Conclusion the combined therapy provided us a more effective strategy for treating the infectious mononucleosis.
同时，体外实验显示，更昔洛韦对人胚成纤维细胞感染HCMV无预防作用。
But GCV had no activity for guarding against human embryo fibroblast cells' infection by HCMV in vitro.
目的探索应用常规剂量更昔洛韦治疗婴幼儿秋季腹泻的确切疗效和临床安全性。
To explore the clinical efficacy of small amount of interferon on treating child autumn diarrhea.
目的探索应用常规剂量更昔洛韦治疗婴幼儿秋季腹泻的确切疗效和临床安全性。
To explore the clinical efficacy of small amount of interferon on treating child autumn diarrhea.
结论更昔洛韦联合强的松能有效改善急性特发性面神经麻痹的预后，无明显不良反应。
Conclusion Ganciclovi with prednisone can improve the neurological function impairment of acute facial palsy, without obvious adverse reaction.
结论更昔洛韦防治异基因造血干细胞移植术后CMV感染效果良好，早期诊断和治疗更为重要。
Conclusion: GCVshows good effect on prevention and treatment of CMV infection after allo-BMT, and an early diagnoses and early treatment is more important.
结果：更昔洛韦组CMV抗原阴转率为40%，尿CMV-DNA阴转率为50%，与对照组比较均有显著性差异；
Results: In treatment group the CMV - Ag negative rate is 40% , CMV - DNA negative rate is 50%, there are significantly differences in two group.
结论更昔洛韦原位胶化滴眼液同一般滴眼液相比，明显延长药物在眼部的滞留时间，增加角膜组织和房水中的药物浓度。
Conclusions 0.2% ganciclovir in-situ gelling eye drops significantly increases the drug penetration into cornea and aqueous humor, and prolongs the residence time in cornea and aqueous humor.
结论： 更昔洛韦对HCMV感染细胞后显示出显著的抑制作用，且随药物浓度的增加其作用逐渐增强，存在明显的量效关系。
Conclusion: The above datas in vitro experimentation revealed that GCV can resist HCMV, and the inhibition effect would be strengthened with the increasing dose of GCV. It showed cleardose connection.
相比目前使用的水或甲醇溶剂纯化收率30％，发现以丙酮、乙酸、水的溶剂体系，精制更昔洛韦收率可显著提高到83.3％，高效液相色谱（HPLC）分析，产品纯度达到99.0％以上。
Ganciclovir could be purified to more than 99.0%(HPLC) by a combination of acetone, acetic acid and water in 83.3% recovery as compared with 30% one when using water or methanol as solvent.
相比目前使用的水或甲醇溶剂纯化收率30％，发现以丙酮、乙酸、水的溶剂体系，精制更昔洛韦收率可显著提高到83.3％，高效液相色谱（HPLC）分析，产品纯度达到99.0％以上。
Ganciclovir could be purified to more than 99.0%(HPLC) by a combination of acetone, acetic acid and water in 83.3% recovery as compared with 30% one when using water or methanol as solvent.
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