Objective: to establish a stable cell line that can be induced to express a target gene.
目的：建立一个可诱导表达目的基因的细胞系以研究新基因的功能。
The VHL gene may be useful as a marker gene for the diagnosis of RCC and as a target gene for molecular therapy.
VHL基因可作为临床诊断指标，并可望成为肾透明细胞癌基因治疗的重要目的基因。
The method has the advantages of easy feasibility and convenient operation, and can fast obtain a target gene segment, in particular a long segment.
该方法易行，操作简便，能够快速的获得目的基因片段，尤其是长片段。
Since humans have the same gene, the team thinks it may serve as a potential target for drugs to prevent obesity.
既然人类有一样的基因，研究小组认为研究结果有潜力去开发更有效的减肥药。
But it can take a long time for the right mutation to occur, especially if there is a very small target, like the region of DNA that controls a gene.
但要得到最合适的变异基因，耗费的时间会非常长，尤其是所要达到目标非常小时，如DNA中用来控制别的基因的区域部分，将是一项旷日持久的工程。
We used a gene therapy technique that enables us to target the brain, but ultimately there could be a pharmaceutical that enhances the signaling pathway solely in the brain.
以往我们曾经使用基因疗法，对大脑进行靶向治疗，最后我们发现可能存在一种药物，它可以单独作用于大脑，增强这条信号通路。
Trastuzumab is a humanised antibody, designed to target and block the function of HER2, a protein produced by a specific gene with cancer-causing potential.
曲妥珠单抗是一种人源化抗体，用于靶向和阻断her2的功能，而后者是由特异基因编码的一种蛋白，具有致癌潜能。
Scientists have discovered a breast cancer gene 30% to 40% of all breast cancers need to survive, offering what could be the biggest gene target yet for "smart bombs" to treat such tumours.
科学家们发现“30%-40%乳腺癌存活者表达乳腺癌相关基因，这些基因可能是这些患者基因靶向治疗最大的靶标”。
The researchers constructed the transposons in such a way that they can carry the therapeutic gene into the target cell DNA.
研究人员构建了转位子，通过转位子携带治疗基因进入靶细胞的DNA 。
Posttranscriptional gene silencing (PTGS) in plants is a form of RNA silencing by which target RNA is degraded in a sequence-specific manner.
植物中的转录后基因沉默(PTGS)是RNA沉默的一种形式，通过PTGS能对目标RNA进行特异性降解。
To understand how LXR regulates LDLR, the authors examined transcriptional target genes of LXR and identified a gene that encodes a myosin interacting protein, IDOL.
为了了解LXR如何调节低密度脂蛋白受体，作者研究了LXR靶基因的转录，并确定了一个能编码肌球蛋白互动蛋白的基因，IDOL。
METHODS: We analyzed the gene sequences and protein structures of BMP-1 and its related proteins, and chose a highly conserved fragment as target gene.
方法：通过分析BMP - 1类各种分子的基因序列及蛋白结构，选择其中的一个片段作为目的基因。
A conditional expression model, in which the target gene is deleted in the presence of a tetracycline derivative, was used to delete the VEGF gene from podocytes.
一个有条件的表达模型用来从足突细胞中删除VEGF基因，在四环素衍生物的出现下靶基因被删除。
A combined 678 bp sequence which containing promoter, initiation codon and NKND sequence can be used for further research of target antigen gene of pan species monoclonal antibody M26~32.
表明可合并组成一段含启动子、起始密码子和NKND四个氨基酸的678个碱基的单克隆抗体M26～32抗原决定簇基因片段。
Now, gene therapy technique has been introduced into the field of periodontology as a new hope to reach the target.
基因治疗技术引入牙周病治疗的研究领域，为这一目标的实现带来了新的希望。
It suggests that although -1892 and -1837 loci are far from the promoter, they may play a remote regulation on the target gene expression.
提示- 1892和- 1837两位点虽不在启动子区，但可能对靶基因表达具有一定的远端调控作用。
Unlike a genetic mutation that changes the function or activity of a gene, which can be inhibited by a well-tailored drug, loss of a gene leaves nothing for the drug to target.
不同的基因突变改变了功能或活动的一个基因，它可以抑制一种非常合适的药物，失去了基因树叶什么药物目标。
Thus XAF1 is a new cancer inhibiting gene and may become a new target to treat carcinoma.
因此，XAF1是一个新的肿瘤抑制基因，有可能成为肿瘤治疗的新靶向基因。
The zinc-finger design allows us to target a single gene, while the nuclease disrupts the gene.
我们可以通过对锌指的设计来靶向单个（特定的）基因，与此同时，核酸酶的存在将破坏该基因。
As Thompson began to study the gene, he found that it was a target for a tumor suppressor gene called p53, which is a major controller of cell activity in prostate and other cancers.
当Thompson开始研究这个基因时，他发现RTVP - 1基因是肿瘤抑制基因p53的靶基因，p 53是前列腺癌及其他癌症细胞活性的最主要控制者。
VEGF and its receptor-FLK - 1 may be the target gene of UPR, suggesting a mechanism of homeostasis of HBMEC under stress.
推测VEGF及其受体FLK一1可能为UPR的靶基因，这可能是人脑微血管内皮细胞在应激状态下保持自身稳定性的一种机制。
The study team targeted the gene by giving trial participants a mimic of its natural target, ribavirin.
该研究团队为参加扎提供了一种模拟其天然靶点——利巴韦林，借此靶向研究其基因。
Conclusion PNA combining with the DNA of target sequence had a highly specificity. Choosing PNA as the probe may improve the determined specificity of piezoelectric gene sensor.
结论PNA与靶序列dna结合有高度的特异性，选用PNA作探针，可提高压电基因传感器检测的特异性。
AIM: To study the specificity of the expression of PEG10 in HCC tissues and evaluate the feasibility for PEG10 as a novel molecular target of gene therapy for HCC.
目的：研究遗传印记基因PEG10在肝癌组织中表达的特异性，及在不同肿瘤细胞中的表达情况，为其作为一个潜在的肝癌特异标志物和HCC基因治疗的新的分子靶点提供实验依据。
Both PR-A and PR-B are ligand activated, but differ in their relative ability to activate target gene transcription (3, 4).
PR A和PR B都是配体激活，但其激活靶基因转录的相对能力是不同的(3,4)。
HDAC activity plays a key role in the regulation of gene expression, and HDAC is a clinically validated cancer target.
HDAC活性在基因表达的调控中发挥关键作用，HDAC是一种经过临床验证的癌症靶标。
HDAC activity plays a key role in the regulation of gene expression, and HDAC is a clinically validated cancer target.
HDAC活性在基因表达的调控中发挥关键作用，HDAC是一种经过临床验证的癌症靶标。
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