Objective: to establish an HPLC method for the resolution of metoprolol enantiomer using chiral mobile phase additives.
目的：建立hplc手性流动相添加剂法拆分美托洛尔对映体的方法。
In part III to VI, ephedrine, tyrosine methyl ester, metoprolol, ibuprofen enantiomeric separation with chiral additive as mobile phase by high performance liquid chromatography are presented.
本论文的第三至第六部分介绍了高效液相色谱手性流动相添加剂法拆分麻黄碱、对羟基苯甘氨酸甲酯、美托洛尔、布洛芬对映体。
The effects of composition of mobile phase, the structure of solute and the column temperature on chiral separation were extensively studied. The chiral recognition mechanism was discussed.
考察了流动相组成、溶质结构和柱温对对映体分离的影响，并初步探讨了手性识别的机理。
A chiral column with a-acid glycoprotein bounded to silica as stationary phase was used with mobile phase of 0.
采用以a-酸性糖蛋白键合硅胶为固定相的手性色谱柱，0。
Separations based on formation of diastereomeric ion-pairs were fulfilled in systems with an organic mobile phase using achiral and chiral stationary phases.
应用手性和非手性柱固定相，在正相色谱系统中，手性药物和手性离子对试剂形成非对映离子对复合物，从而使手性药物得以分离。
The chromatographic conditions were optimized using different alcohols as mobile phase modifier. The effect of temperature on chiral separation was investigated.
通过选择不同结构、不同碳数的醇做流动相的极性改性剂，优化了色谱分离结果。
Similar to chiral silica-based monoliths, chiral organic polymer-based monoliths possess large pores which allow convective flow of mobile phase and result in high flow rates at reduced pressure drop.
与手性硅基整体柱相似，手性有机聚合物整体柱由于具有大孔，可产生较高的流速而压降较小。
Similar to chiral silica-based monoliths, chiral organic polymer-based monoliths possess large pores which allow convective flow of mobile phase and result in high flow rates at reduced pressure drop.
与手性硅基整体柱相似，手性有机聚合物整体柱由于具有大孔，可产生较高的流速而压降较小。
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