The invention relates to a novel inhibitors of chymase.
本发明涉及新的胃促胰酶抑制剂。
Chymase is one of the major proteases in the secretory granules of mast cells.
类糜蛋白酶是肥大细胞分泌的主要中性蛋白酶之一。
Chymase is a kind of serine proteinase, mainly exists in secretory granules of mast cell and extracellular Interstitium.
糜酶是一类丝氨酸蛋白酶，主要存在于肥大细胞的分泌颗粒和细胞间质。
SLPI possesses potent inhibitory activity against neutrophil elastase, cathepsin g, chymase, trypsin and chymotrypsin and play an important role in allergic and inflammatory diseases.
SLPI能抑制中性粒细胞的弹性蛋白酶、组织蛋白酶g、肥大细胞的类糜蛋白酶、胰蛋白酶和糜蛋白酶，在变态反应性疾病和炎症中起重要作用。
SLPI possesses potent inhibitory activity against neutrophil elastase, cathepsin g, chymase, trypsin and chymotrypsin and play an important role in allergic and inflammatory diseases.
SLPI能抑制中性粒细胞的弹性蛋白酶、组织蛋白酶g、肥大细胞的类糜蛋白酶、胰蛋白酶和糜蛋白酶，在变态反应性疾病和炎症中起重要作用。
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