Objective: to establish an HPLC method for the resolution of metoprolol enantiomer using chiral mobile phase additives.
目的：建立hplc手性流动相添加剂法拆分美托洛尔对映体的方法。
Many methods were investigated for the synthesis of the single enantiomer of the chiral intermediate, including chemical resolution, chemical asymmetric synthesis and chemo-enzymatic synthesis.
研究人员采用多种方法合成单一构型的地尔硫卓手性中间体，其中包括化学拆分、化学不对称合成以及化学-酶法合成等方法。
It was found that resolution of enantiomer of neutral compound was enhanced by adding certain amount of methanol.
同时发现，一定含量的甲醇可以提高中性化合物对映体分离度。
It was found that resolution of enantiomer of neutral compound was enhanced by adding certain amount of methanol.
同时发现，一定含量的甲醇可以提高中性化合物对映体分离度。
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