Objective To evaluate the efficacy and safety of domestic lovastatin.
目的评价国产洛伐他汀的疗效和安全性。
OBJECTIVE: To optimize the formulation and technology of Lovastatin tablets.
目的：对洛伐他汀片的生产工艺进行改进和优化。
Objective To review the advances on lovastatin fermentation by Aspergillus terras.
目的综述土曲霉洛伐他汀发酵研究的进展。
Protective effects of lovastatin on vascular endothelial function were reversed by L-NNA.
洛伐他汀对血管内皮功能的保护作用能被L - NNA所阻断。
The mechanism of lovastatin was related to enhance NO pathway and inhibit oxidative stress.
其作用机制可能与洛伐他汀增强NO通路和抗氧化作用有关。
Methods: The molecular weight of products from bio-transformation of lovastatin was determined by HPLC/MS.
方法：应用HPLC/MS技术测定转化产物的相对分子质量。
The process of lovastatin extraction from fermentation is studied and optimal conditions are determined through experiments.
通过实验研究确定了从洛伐他汀发酵液中提取洛伐他汀的最佳工艺条件。
In the process of manufacturing Lovastatin Tablets, two kinds of refuses, fermentation refuse and refining refuse, are produced.
洛伐他汀生产过程中产生发酵渣和提炼渣。
Objective To study the effect of lovastatin on the cell cycle and proliferation of human highly metastatic ovarian carcinoma HO-8910PM cells.
目的探讨洛伐他汀对人高转移卵巢癌细胞HO- 8910 PM细胞周期和增殖的影响。
After flight, the strain was rejuvenized, segregated and selected. The content of Lovastatin produced in the solid fermentation was examined.
对搭载后的菌株进行复壮、分离和筛选，并进行固体发酵，检测发酵产物中洛伐他汀产量。
Methods a total of 180 patients with hyperlipidemia were randomly assigned into the metronidazole combined with lovastatin group or the metronidazole alone group.
方法选取高脂血症病人180例，随机分为两组，治疗组用甲硝唑合洛伐他汀联合治疗；对照组单用甲硝唑治疗。结果两组治疗效果非常显著P。
Objective To study the efficacy and adverse effects of lovastatin combined with metronidazole in treatment of hyperlipidemia, and to explore its possible mechanisms.
目的观察小剂量甲硝唑合洛伐他汀调治高脂血症的疗效与副作用，并探讨其可能的机理。
Conclusion lovastatin could inhibit the proliferation of HL-60 cell lines in vitro, and the effect of lovastatin on cell cycle and cell apoptosis maybe play key role.
结论洛伐他汀可能通过影响细胞的生长周期和诱导细胞凋亡来抑制HL - 60细胞的增殖。
Result mutants with high productivity of Lovastatin were obtained. A series of tests showed that the acquired character of the mutants was stable. Conclusion Space flight is an effective...
结果从众多分离到的变异菌株中筛选到十几株高产洛伐他汀的菌株，一系列实验表明其高产性状是稳定的。
Conclusion With the advances of basic research about fungi producing lovastatin in the molecule and cell level, the optimization of lovastatin fermentation technology shows more significance.
结论随着洛伐他汀产生菌的分子、细胞水平基础研究的加强，其发酵工艺的优化将更有意义。
A high performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry method was developed for analysis and identification of impurities in lovastatin.
利用高效液相色谱-二极管阵列检测器-质谱联用方法对洛伐他丁及其杂质成分进行分离分析和结构鉴定。
A high performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry method was developed for analysis and identification of impurities in lovastatin.
利用高效液相色谱-二极管阵列检测器-质谱联用方法对洛伐他丁及其杂质成分进行分离分析和结构鉴定。
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