Objective: To determine the optimum experiment condition of detecting P—glycoprotein with Western blotting.
目的：确定蛋白免疫印迹检测大鼠脑组织中P-糖蛋白的最佳实验条件。
ObjectiveTo establish and research the rat model of refractory epilepsy and investigate the rule of P-glycoprotein expression to make the mechanism of drug resistance clear.
目的建立大鼠难治性癫痫模型并观察其特点及研究多药物耐药蛋白P-糖蛋白表达规律，探讨癫痫耐药机制。
TTD may act by means of suppressing the function of the P-170 glycoprotein in drug-resistant tumor cells.
推测ttd可能是通过抑制耐药肿瘤细胞膜上P - 170糖蛋白的功能而起作用的。
PSGL-1 (P-selectin glycoprotein ligand 1) is a mucin expressed on microvilli of almost all types of leukocytes.
选择素糖蛋白配体1）是一种组成性地表达于几乎所有白细胞微绒毛上的黏蛋白。
The secondary objective was to determine whether the magnitude of the pharmacokinetic interaction was influenced by P-glycoprotein genetic polymorphism.
其次，分析药物药代动力学的改变程度是否与P -糖蛋白的遗传多态性有关。
Inhibitory effects of the flavonoid derivatives on P-glycoprotein (P-gp) -mediated drug efflux have attracted more and more interest of researchers.
黄酮类化合物对P糖蛋白外泵作用的抑制效果越来越引起人们的关注。
Objectives: Grapefruit juice is responsible for drug interactions mediated by intestinal cytochrome P4503A4 inhibition and possibly P-glycoprotein inhibition in enterocytes.
目的：葡萄柚汁通过对小肠细胞色素P4503A4和潜在性对肠上皮细胞P-糖蛋白的抑制作用，进而影响药物代谢。
Platelet activation by P-selectin and monocyte cell surface P-selectin glycoprotein ligand - 1 combine to form PMA.
血小板活化后，通过P -选择素和单核细胞表面的P -选择素糖蛋白配基-1结合形成PMA。
But the activity of GSH-PX in P-glycoprotein positive and poor effect negative patients have increased.
糖蛋白表达阳性和阴性疗效差者GSH活力均增高。
The p-glycoprotein (P-gp) expression was determined by immunohistochemistry analysis.
免疫组化方法测定细胞表面P -糖蛋白表达。
Phenylbutyrate induced P-glycoprotein and BCRP expression and the efflux of drugs as determined with labeled substrates.
苯丁酸诱导P糖蛋白和BCRP的表达和药物的外向通量由标记底物来决定。
P-glycoprotein inhibitors can get drugs across the blood-brain barrier. It is of great importance to improve the blood concentration in brain and bioavailability of central nervous system drugs.
糖蛋白抑制剂可促进药物通过血脑屏障，对提高脑内药物的浓度和中枢神经系统药物的生物利用度具有重要意义。
Objective To review the development of the key role of P-glycoprotein (P-gp) in the intestinal absorption of drugs during the past five years.
目的综述近五年来多药耐药性p糖蛋白作用于药物肠道吸收过程的研究进展。
Conclusion the P-glycoprotein-mediated MDR may be an important cause of recurrent of bladder cancer after treated by perfusion chemotherapy.
结论P -糖蛋白介导的多药耐药是膀胱癌腔内灌注化疗失败、肿瘤复发的重要原因。
Results A little tumor associated glycoprotein were detected in the feces of the patients suffering from benign intestine lesion and the healthy persons, and non-distinct differences(P>0.05).
结果正常人及非恶性胃肠道疾病患者粪便中可含有少量癌相关抗原，且两者之间无显著差异（P >0 0 5 ）。
Results A little tumor associated glycoprotein were detected in the feces of the patients suffering from benign intestine lesion and the healthy persons, and non-distinct differences(P>0.05).
结果正常人及非恶性胃肠道疾病患者粪便中可含有少量癌相关抗原，且两者之间无显著差异（P >0 0 5 ）。
应用推荐