OBJECTIVE to determine the inhibitory effect of rutaecarpine (WZY) on cytochrome P450s in human liver microsome.
目的研究吴茱萸次碱(WZY)在人肝微粒体中对细胞色素P 450酶的抑制作用。
METHODS: Evodiamine and rutaecarpine were extracted with the solvent ethyl acetate and the ultrasonic extractor.
方法：以乙酸乙酯为溶剂用超声震荡提取法提取吴茱萸碱和吴茱萸次碱。
Objective: To investigate the effect of rutaecarpine on the ventricular fibrillation threshold (VFT) of isolated rat heart.
目的：研究吴茱萸次碱对离体大鼠室颤阈的影响。
Result The experiment show that decoction time and menstruum dosage have the evidence influence on extracting rutaecarpine, and decoction hour take second place.
结果实验表明，煎煮次数、溶媒用量对吴茱萸次碱的提取影响较大，煎煮时间则次之。
OBJECTIVE To determine whether the protection of rutaecarpine against myocardial ischemia-reperfu-sion injury is related to the activation of capsaicin-sensitive sensory nerves in rats.
目的观察吴茱萸次碱对大鼠心肌缺血再灌注损伤的保护作用是否与激活辣椒素敏感的感觉神经有关。
RESULTS: The material basis of the Wuzhuyu decoction was found to be produced chiefly by the chemical constituents contained in No. X4, X9 (rutaecarpine), X10 and X12 chromatographic peaks.
结果：确定吴茱萸汤的药效物质基础主要为产生X4，X9，X10和X12号色谱峰中的化学成分（已确认X9为吴茱萸次碱）。
RESULTS: The material basis of the Wuzhuyu decoction was found to be produced chiefly by the chemical constituents contained in No. X4, X9 (rutaecarpine), X10 and X12 chromatographic peaks.
结果：确定吴茱萸汤的药效物质基础主要为产生X4，X9，X10和X12号色谱峰中的化学成分（已确认X9为吴茱萸次碱）。
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