Conclusion: Plasma Fbg concentration and fibrin monomer polymerize function were decrease, showed that patients were low coagulation state and contributing to one cause of hemorrhage.
结论：失代偿性肝硬化患者因纤维蛋白原浓度下降致使纤维蛋白单体聚合功能降低，从而出现低凝状态，这可能是构成出血倾向的原因之一。
OBJECTIVE To investigate the association between valproic acid (VAP) plasma concentration at steady state (Css) and CYP2C19 gene polymorphisms for better individualized medication.
目的：寻找丙戊酸药物浓度与CYP2C19基因多态性的关系，以便临床根据患者的基因型进行个体化给药。
When VPA is administrated alone, the standardized plasma concentration at steady state (Csss) of VPA is higher in poor metabolism patients than that in normal metabolism patients ( P< 0. 05).
单一应用VPA时，弱代谢患者较正常代谢患者的VPA血药浓度有所升高（P<0.05）。
When VPA is administrated alone, the standardized plasma concentration at steady state (Csss) of VPA is higher in poor metabolism patients than that in normal metabolism patients ( P< 0. 05).
单一应用VPA时，弱代谢患者较正常代谢患者的VPA血药浓度有所升高（P<0.05）。
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