目的：制备米托蒽醌固体脂质纳米粒并优化其处方组成。
OBJECTIVE to prepare and optimize the composition of mitoxantrone solid lipid nanoparticles.
结论溶剂乳化法适用于水飞蓟素固体脂质纳米粒的制备。
ConclusionThe solvent - emulsifying method is suitable for preparation of silymarin SLN.
固体脂质纳米粒通常是由固体脂质材料经高压乳匀法制备而成。
Solid lipid nanoparticles (SLN) are nanoparticles generally made from solid lipids by high pressure homogenization.
通过整理和归纳国内外文献，介绍固体脂质纳米粒的最新研究进展。
To introduce the latest research advances on solid lipid nanoparticles by referring to the domestic and international documents.
方法用水性溶剂扩散法，制备得到甘油单硬脂酸酯固体脂质纳米粒。
Methods Monostearin solid lipid nanoparticles was prepared by solvent diffusion method in aqueous system.
就固体脂质纳米粒提高难溶性药物生物利用度的机理及应用作一介绍。
This paper reviews the mechanism and application of SLN for enhancing the bioavailability of poorly soluble drugs.
固体脂质纳米粒作为一种新型给药系统，可以提高难溶性药物生物利用度。
Solid lipid nanoparticles is a new drug delivery system, which can enhance the bioavailability of poorly soluble drugs.
目的制备咪喹莫特固体脂质纳米粒，并考察其理化性质及其对透皮的影响。
OBJECTIVE To prepare imiquimod-loaded solid lipid nanoparticles and investigate their properties and transdermal permeation.
本发明公开了一种黄芩天然活性成分的固体脂质纳米粒及其制剂制备方法。
The present invention discloses nanometer solid lipid particle of active skullcap components and its preparation.
目的本研究对所制得的芹菜素固体脂质纳米粒的制剂学性质和药动学进行研究。
OBJECTIVE To investigate the pharmacy characters and pharmacokinetic processes of the prepared apigenin loaded solid lipid nanoparticles (AP-SLN).
以自制芹菜素混悬液为对照组，考察了大鼠口服芹菜素固体脂质纳米粒的药动学过程。
The pharmacokinetic processes of oral AP-SLN of the rats were also studied, while apigenin suspension was used as control group.
目的：制备10 -羟基喜树碱的半固体脂质纳米粒(HCPT -SSLN)并考察其稳定性。
Objective: to prepare 10-hydroxycamptothecin-semisolid lipid nanoparticles (HCPT-SSLN) and investigate its stability.
摘要：目的制备地西泮固体脂质纳米粒，评价其制剂学性质，并探讨其经鼻腔给药后的药动学过程。
ABSTRACT: OBJECTIVE To prepare diazepam solid lipid nanoparticles, evaluate the pharmacy characters and study the pharmacokinetics after intranasal administration.
方法以硬脂酸为载体采用溶剂乳化法制备水飞蓟素固体脂质纳米粒，并用葡聚糖凝胶层析法测定其包封率。
Method Silymarin SLN was prepared through the solvent-emulsifying method with stearic acid as the carrier, and the encapsulation rate was determined with the Sephdex gel chromatogram.
对固体脂质纳米粒(SLN)作为药物载体的最新研究进展进行了综述，指出SLN在药学领域的广阔发展前景。
The development of the solid lipid nanoparticles (SLN) as a pharmaceutical carrier is reviewed. It is suggested that the SLN has broad prospects in the pharmaceutical field.
结果超滤法能有效地将石杉碱甲固体脂质纳米粒与游离石杉碱甲分离，回收率为98.09%，测得3批样品的平均包封率为57.63%。
Results Free drugs could be effectively separated from the Hup ASLN by ultrafiltration. The average entrapment efficiency of three batches of Hup ASLN was 57.63%, with the recovery of 98.09%.
结果超滤法能有效地将石杉碱甲固体脂质纳米粒与游离石杉碱甲分离，回收率为98.09%，测得3批样品的平均包封率为57.63%。
Results Free drugs could be effectively separated from the Hup ASLN by ultrafiltration. The average entrapment efficiency of three batches of Hup ASLN was 57.63%, with the recovery of 98.09%.
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