GJB2基因敲除小鼠在胚胎期致死。
GJB2 gene knockout mice led to death during embryonic period.
另外，该基因敲除小鼠可以作为研究躁狂症的模型。
In addition, the knockout mice might be useful as models to study mania.
结论套环能加速载脂蛋白e基因敲除小鼠颈总动脉斑块形成。
Conclusions Perivascular common carotid collar placement can accelerate atherosclerotic plaque formation in apolipoprotein E-knock out mice.
目的研究蚤休水提液对载脂蛋白E基因敲除小鼠晚期斑块的影响。
Objective: To study the effects of water extract from Paris Polyphylla Smith on advanced plaques in ApoE gene knockout mice.
其次，D3R基因敲除小鼠研究提示，正常生理状态下D3R仅表现辅助功能；
The D3R knock-out mice have also been generated. The results from these mice show D3R plays a secondary role in physiological condition.
另外，该基因敲除小鼠可以作为研究躁狂症的模型。现在还没有可用于躁狂症的动物模型。
In addition, the knockout mice might be useful as a model to study mania, as there is no other animal model available yet.
尽管整体心室壁厚度下降，但是特定区域的形态学改变和基因敲除小鼠的心室壁粘液瘤的形成一致。
Although heart wall thickness was reduced overall, specific areas exhibited morphological changes consistent with myxomatous degeneration in the walls of knockout hearts.
最近的研究表明，COX-2基因敲除小鼠的生殖缺陷主要依赖小鼠的遗传背景，与小鼠的品系相关。
However, it was recently shown that the reproductive defects of COX-2-deficient mice mainly depend upon genetic background of the mouse strains.
我们的研究团队在2004年对基因敲除小鼠进行的研究发现，这类小鼠的神经功能丧失部分地减少了。
Our group has shown in 2004 that in knockout mice that are partially protected from a loss in nerve function.
在AEP基因敲除的小鼠实验中，该药物及人为中风所导致的DNA损伤与脑细胞死亡均比非基因敲除小鼠程度减轻。
In mice genetically engineered to lack AEP, both the drug and an artificial stroke resulted in reduced DNA damage and less brain cell death than in regular mice.
来自澳大利亚的MichaelMathai及她的同事研究了血管紧张素转换酶基因敲除小鼠，该基因编码肾素-血管紧张素系统中一种关键蛋白。
Michael Mathai and colleagues in Australia examined mice that were missing a gene that encodes for angiotensin-converting enzyme, a key protein for the renin-angiotensin system.
这种基因敲除程序现在已经被普遍用于小鼠和大鼠，3名研究人员因为发明了这种“基因打靶”技术获得了2007年的诺贝尔奖。
These knockout procedures are now commonly done in mice and rats, and three researchers earned a Nobel prize in 2007 for developing this method, called "gene targeting".
为了更具体的验证这个途径，研究者把小鼠的DDAH基因敲除。
To examine this pathway in more detail, the researchers deleted the DDAH gene in mice.
研究人员说，下一步实验将研究敲除小鼠RSOP1基因后产生的变化。
The next step, say the researchers, is to find out what happens when the RSOP1 gene is knocked out of mice.
他们发现这种敲除基因的小鼠骨髓中的淋巴细胞较正常鼠少50%，产生特异免疫细胞的胸腺较正常鼠少80%。
They found that the knockout mice had 50 percent fewer lymphocytes in their bone marrow and 80 percent fewer in their thymus, a collection of glands that helps produce specialized immune cells.
雌性野生种小鼠的丙氨酸转氨酶是基因敲除鼠的4倍，这提示肝损伤的存在；
Female wild-type mice on an ethanol-rich diet had 4 times as much alanine aminotransferase (ALT), indicating liver injury, than mice lacking the osteopontin gene.
小鼠ptp - 1b基因敲除及反义核苷酸治疗实验表明PT P - 1b是治疗糖尿病和肥胖症的潜在靶标。
Recent PTP-1B gene knock-out studies and anti-sense oligonucleotide (ASO) treatment in mice have identified PTP-1B as a potential target for chemotherapy of diabetes and obesity.
方法：通过敲除小鼠叉头框c 2基因，解析敲除叉头框c 2基因小鼠的心脏发育情况。
Methods Fox C2 deficient mice were reproduced by targeting mutation and the developmental anomaly in heart was analyzed.
以前的研究表明，COX - 2基因敲除的小鼠是不孕的，并且排卵、受精、着床以及蜕膜化均出现异常。
A previous study showed that COX-2-deficient females are infertile with abnormalities in ovulation, fertilization, implantation and decidualization.
PTEN基因敲除的小鼠是一种慢性肝损伤模型，最终导致肝癌。
The PTEN knock-out mouse is one model of chronic liver injury that ultimately leads to liver cancer.
结论：敲除叉头框c 2基因可使小鼠室间隔发育缺损。
Conclusion Targeting mutation of Fox C2 gene can result in ventricular septal defect.
结论DPR基因敲除型小鼠脑中组胺能神经活性显著降低，这一变化可能是该种小鼠尚能维持正常睡眠的代偿机制之一。
Conclusion The activity of the histaminergic system decreased and the decrease might be one of the compensatory mechanisms for maintenance of the normal sleep in the null mice lacking DPR.
研究人员使用经过基因敲除的小鼠来做实验，这些小鼠的舌头中缺乏特定的味觉受体。
The researchers also conducted experiments using knockout mice lacking specific taste receptors in their tongues.
Saltiel说：“在这项研究中，基因敲除的小鼠并没有比对照组小鼠进行更多的运动。”
"The knockout mice are not exercising any more than the control mice used in the study. They're just burning more energy," Saltiel said.
Saltiel说：“在这项研究中，基因敲除的小鼠并没有比对照组小鼠进行更多的运动。”
"The knockout mice are not exercising any more than the control mice used in the study. They're just burning more energy," Saltiel said.
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