目的了解大环内酯抗生素抗炎效应的细胞学机制。
Aim to evaluate the cellular mechanism of the anti inflammatory action of macrolide.
因此，开发新的抗耐药菌大环内酯抗生素已成为当前药物研究的热点。
Therefore, it has attracted extensive attention to develop new potent macrolides against resistant bacteria.
因此，基于新靶点设计合成抗耐药菌大环内酯抗生素，是解决细菌耐药性的一条重要途径。
Therefore, design and synthesis of new macrolide derivatives against resistant bacteria based on new target sites is an important way to overcome bacterial resistance.
抗菌机制研究表明：大环内酯抗生素的作用靶点位于50S亚基肽通道的出口处，紧邻肽酰转移酶中心。
The mechanism of macrolide's action indicates that the binding sites of macrolides are located inside the nascent peptide exit tunnel of the ribosomal 50S subunit near the peptidyl transferase center.
从上个世纪五十年代大环内酯抗生素上市以来，已有20余种用于临床，在抗感染领域发挥着十分重要的作用。
More than 20 kinds of macrolide antibiotics, which have been used since the early 1950s, have been playing an important role in clinic.
本品为大环内酯类抗生素。
大环内酯类抗生素的基因工程研究进展十分迅速。
The study of gene engineering of macrolide antibiotics have made the rapid and exciting progress.
结果表明，在维港海水中，只检出较低含量的氟喹诺酮和大环内酯类抗生素；
The results showed that the concentrations of antibiotics were mainly below the limit of quantification(LOQ) in the ambient marine water of Victoria Harbour.
目的建立大环内酯类抗生素微生物限度检查方法。
Objective To establish a method for microbial limit test of macrolide antibiotics.
雷帕霉素是一种大环内酯类抗生素。
大环内酯类抗生素耐药菌比例比其他族类抗生素高，在医院环境中表现出最高的耐药菌比例；
Proportion of macrolide antibiotic was higher than other antibiotics and demonstrated the highest proportion in hospitals.
四环素类、大环内酯类、喹诺酮类抗生素是治疗解脲支原体感染的主要有效药物。
Tetracyclines macrolides and quinolones are the effective antibiotics in the treatment of these diseases.
纳他霉素是一种多烯大环内酯类抗真菌抗生素，能专一地抑制酵母和霉菌，作为天然的防腐剂用于食品和饲料行业。
Natamycin is a kind of polyene macrolide antifungal antibiotic not only specifically represses yeast and fungi but also plays as a natural antiseptic in food and forage industry.
红霉素是糖多孢红霉菌合成的次生代谢产物，为一类广谱大环内酯类抗生素，在临床上具有广泛的应用。
Erythromycin is the secondary metabolite of Saccharopolyspora erythraea. It is a broad spectrum macrolide antibiotic and clinically used widely.
红霉素是一类广谱大环内酯类抗生素，在临床上具有广泛的应用。
Erythromycin is a broad spectrum macrolide antibiotic and clinically used widely.
结论：新一代大环内酯类抗生素阿奇霉素注射剂，治疗急性细菌性下呼吸道感染安全有效。
Conclusion: New generation of macrolides, azithromycin is a safe and effective antibacterial agent for the treatment of acute bacterial infections of lower respiratory tract.
目的：探讨大环内酯类抗生素的不良反应及用药安全性。
Objective: To study the macrolide antibiotic adverse reaction and safety of drug application.
大环内酯类抗生素是治疗MP感染的有效抗生素。
Macrolides are the effective antibiotics in the treatment of MP infection.
最受人重视的抗生素是庆大霉素、最主要的特征是产生氨基糖苷类抗生素和大环内酯类抗生素。
It was found that production of aminoglycoside and macrolide antibiotics by the microorganisms was most characteristic.
本发明描述了大环内酯多烯抗生素或其衍生物或类似物作为培养物补充物用于病毒繁殖的用途。
The use of macrolide polyene antibiotics or derivatives or analogues thereof as culture supplement for the propagation of virus is described.
泰拉霉素是动物专用的新型大环内酯类抗生素，国内已批准用于猪呼吸系统疾病的防治。
Tulathromycin is a novel macrolide antibiotic for animals which has been approved for use in the prevention and treatment of swine respiratory disease in China.
罗红霉素为新型大环内酯类抗生素，其体外抗菌活性类似于母体化合物红霉素。
Roxithromycin, a new macrolide antibiotic, has an antibacterial spectrum similar to that of erythromycin.
第二代大环内酯类抗生素具有良好的抗菌活性和酸稳定性，但是目前耐药性问题成为当务之急。
The second generation macrolide antibiotics has the satisfactory antibacterial activity and the stability in acid. But the tolerance has been the urgent problem.
研究表明，大环内酯类抗生素能与细菌核糖体50s亚单位的L 2 7及L 2 2蛋白质结合，抑制细菌的蛋白合成而发挥抗菌作用。
Studies showed that macrolide antibiotics exert antimicrobial effects by binding to L27 and L22 protein of the 50s subunit of bacterial ribosomes and inhibiting protein synthesis.
本发明提供了一种制备大环内酯类抗生素衍生物的一种中间体红霉素A - 9 -肟化合物的制备新工艺。
The present invention is new technological process of preparing erythromycin A-9-oxime compound as one intermediate of macrolide antibiotics.
持续发热可能是MP肺外并发症的相关因素之一，早期大环内酯类抗生素的应用可以减少MP肺外并发症的发生。
Persistent fever may be an important correlative factor of extra-pulmonary complications caused by mp, and early therapy of macrolide can reduce the extra-pulmonary complications.
持续发热可能是MP肺外并发症的相关因素之一，早期大环内酯类抗生素的应用可以减少MP肺外并发症的发生。
Persistent fever may be an important correlative factor of extra-pulmonary complications caused by mp, and early therapy of macrolide can reduce the extra-pulmonary complications.
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