目的：合理设计新的HIV-1整合酶抑制剂。
Objective: To rationally design new inhibitors of HIV-1 integrase.
整合酶抑制剂MK- 0518对以前没接受过抗病毒治疗病人，疗效就像目前最好的药物组合一样有效。
The integrase inhibitor MK-0518 worked as effectively as the best treatment available for individuals who have not previously received antiretroviral therapy.
给出了各个代表性体系的应用价值。旨在对HIV - 1整合酶抑制剂药物设计及筛选平台的建立提供一定的参考。
The application value of each representative system was evaluated to provide some guidance for the platform established for the drug design and screening of HIV-1 integrase inhibitors.
整合酶抑制剂；首次获准：2007年；抗病毒方式：整合酶抑制剂干预了整合酶酵素，艾滋病病毒正是通过整合酶酵素将自己的遗传物质传到人类细胞。
Integrase inhibitors 2007 integrase inhibitors interfere with the integrase enzyme, which HIV needs to insert its genetic material into human cells.
三联苯曲菌素还没有被广泛的研究但已报道显示其有抗氧化的活性，做为一种植物生长抑制剂，也显示了弱的抗HIV整合酶的活性。
Terphenyllin has not been extensively studied but has been reported to exhibit anti-oxidative activity, acts as a plant growth inhibitor and shows weak activity against HIV integrase.
三联苯曲菌素还没有被广泛的研究但已报道显示其有抗氧化的活性，做为一种植物生长抑制剂，也显示了弱的抗HIV整合酶的活性。
Terphenyllin has not been extensively studied but has been reported to exhibit anti-oxidative activity, acts as a plant growth inhibitor and shows weak activity against HIV integrase.
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