这种紧密的结构可以阻碍基因转录和染色质的重塑 ( chromatin remodeling), 改变核小体与 DNA的相对位置和空间结构, 为转录因子与基因 启动子的结合提供条件。
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已有研究表明DNA顺式作用元件与反式作用因子之间的相互作用是染色质重塑和基因转录调节的基础。
Present studies indicate that the interactions between trans-acting factors and corresponding DNA cis-acting elements are the basis of chromatin remodeling and gene transcription regulation.
表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。
Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.
参与染色质重塑的基因明确受影响。
Specifically affected were genes involved in chromatin remodeling.
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