Objective To construct a bivalent VP1 gene vaccine against Coxsackie virus B1 and B3 (CVB1 and CVB3) and to test its immunogenicity in mice.

目的构建柯萨奇病毒（CV）B1/B3型二价VP1基因免疫质粒，并探讨其免疫原性。

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Coxsackie B virus is also a common virus, most prominently affecting children.

柯萨奇b病毒也是一种常见的病毒，最显著地感染儿童。

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HN is a common virus, Coxsackie virus, other parts may cause respiratory tract infections.

HN病毒是一种常见病毒，会引起呼吸道等部位感染。

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There are six different sub-types of Coxsackie B, a virus named after the town in New York state in which it was discovered in 1948.

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