The hardness of the tablets controlled to 4.0 kg/cm2 was comparatively soft and loose, and to 8.0 kg/cm2 took a longer time to disintegrate. Conclusion: In preparing the dispersible tables of traditional Chinese medicine, it is better for disintegrants to adopt the method of mixing PVPPXL into the grains and adding L-HPC to the outside of the grains, for fillers to choose MCC, for moistening agents to be 95% alcohol solution and for the hardness of the tablets to be controlled to 6~7 kg/cm2.
结论:在中药分散片的制备工艺中,崩解剂采用外加L-HPC,内加PVPPXL较好,填充剂选择MCC较佳,润湿剂以95%乙醇溶液为宜,药片硬度控制在6~7 kg/cm2比较理想。
参考来源 - 中药分散片的处方设计与优选试验—《中国医药导报》—2008年第2期—龙源期刊网·2,447,543篇论文数据,部分数据来源于NoteExpress
Conclusion: the pulsatile release of aspirin can be controlled by selection of disintegrants of the core and changing composition and thickness of the coating film.
结论:通过选择片芯中的崩解剂、调整包衣层组成和厚度,可以用包衣的方法得到不同时间脉冲释药的阿司匹林片剂。
These combined disintegrants were selected to obtain the best dosage of azithromycin dispersible tablets according to the fluidity of the granules and the disintegration of tablets.
目的:探讨纯化膨润土和一些常用片剂崩解剂的吸水特性,考察纯化膨润土作为片剂崩解剂的崩解性能。
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