(4)耐药突变株（drug-resistant mutant)：因病毒编码的病毒酶基因的改变而降低了靶酶对药物的亲和力或作用，从而使病毒对药物不敏感而继续增殖。
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OBJECTIVE To investigate the effect of drug concentration, drug structure of fluoroquinolones on the resistant gene of Escherichia coli mutants selected in the mutant selection window (MSW).
目的：研究不同药物浓度、不同化学结构的氟喹诺酮类药物对突变选择窗(MSW)内筛选的大肠埃希菌耐药突变体的靶位耐药基因的影响。
By producing a more accurate model of integrase, the research allows further searches for new drug molecules that will inhibit the mutant drug resistant forms of this enzyme, as well.
通过构建更精确的整合酶模型，这技术使未来未来搜寻新的药物分子成为可能，这些新药物分子将能通过稳定病毒蛋白酶的结构来抑制突变病毒的抗药性。
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