VHL蛋白的底物之一就是缺氧诱导因子（hypoxia-inducible factor, HIF），它在维持哺乳动物细胞内环境中氧稳定状态的过程中起到了关键性的作用。
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是一种由缺氧诱导因子 hypoxia-inducibh factor ; HIF
缺氧诱导因子- 1是近几年研究较多的转录因子，它可使肿瘤在生长侵袭过程中适应缺氧应激，也为肿瘤治疗提供了新思路。
Hypoxia-induced factor-1 is a transcription factor which is widely studied in recent years. It helps progressing tumors adapt to hypoxia stress and also provides a new clue for tumor therapy.
缺氧诱导因子1（HIF-1）是近年发现的调控细胞低氧适应性变化的重要转录因子。
Hypoxia-inducible factor-1(HIF-1), a newly discovered factor in recent years, is an important transcription factor which can control the cells′adaptive responses to hypoxia.
缺氧诱导因子- 1 (H IF - 1)是由低氧等诱导细胞产生的1种转录因子，能激活许多缺氧反应性基因的表达。
Hypoxia inducible factor-l (HIF-1), which can stimulate expression of hypoxia induced-responsed, is a kind of transcriptive factor.
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