组蛋白是染色质的核心,其尾部共价修饰在基因表达调控中有重要作用。
Histone is the core of chromatin, and covalent modification of histone tails have fundamental roles in regulation of gene expression.
目的:构建丙型肝炎病毒(HCV)全长及3种不同缺失突变的核心蛋白基因的原核表达载体,并在大肠杆菌中表达。
AIM: to construct the recombinant plasmids expressing full-length HCV core protein gene and 3 different deletion mutated hepatitis core protein genes and to express them in E. coli.
目的:研究抑癌基因PTEN在人肝细胞肝癌中的表达及其与HCV核心蛋白间的关系。
Objective: To study the relationship between PTEN expression and HCV core protein in hepatocellular carcinoma (HCC).
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