核苷酸切除修复（Nucleotide excision repair），简称NER，是通过损伤识别，把包含全基因组的核苷酸切除修复。
...瘤的化疗,是消化系统肿瘤化疗的传统药物之一,但耐药性的产生严重影响其疗效,目前认为核苷酸切除修复(nucleotide excision repair,NER)是铂类药物耐药的重要机制之一,因其导致耐药的主要机理为清除大规模铂类化舍物所致DNA螺旋扭曲.
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根据作用方式不同主要分四大类:一、碱基切除修复(BER):主要修复被氧化或烷基化损伤的碱基;二、核苷酸切除修复(NER):主要清除紫外线诱导的光产物和由多种化学物质所引起的DNA加合物;三、重组修复(DsB):修复由电离辐射或化学物质引起的DNA双链断裂...
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核苷酸切除修复途径 nucleotide excision repair ; NER
核苷酸切除修复系统 nucleotide excision repair ; NER
核苷酸切除修复基因 Nucleotide excision repair gene
核苷酸切除修复通路 nucleotide exicision repair ; NER
核苷酸切除修复蛋白 NER PROTEINS ; Nucleotide excision repair proteins
只有核苷酸切除修复酶 excision repair cross-complementing ; ERCC
核苷酸切除修复系 nucleotide excision repair
是核苷酸切除修复系统 nucleotide excision repair
目的：探讨核苷酸切除修复基因ERCC1在肺癌中的表达及其与多环芳烃(PAH) - DNA加合物的关系。
AIM: To investigate the expression of nucleotide excision repair gene ERCC1 and its relationship with PAH (polycyclic aromatic hydrocarbons) -dna adducts in lung cancer tissues.
植物可以通过多种途径来修复紫外诱导的DNA损伤，主要包括光修复、碱基切除修复、核苷酸切除修复和重组修复等。
Plant could repair DNA damage induced by UV-B through many methods, mainly included light-repair, base excision repair, nucleotide excision repair and recombination repair etc.
由于核苷酸切除修复、药物转运和药物代谢通路在铂金药物功能中的重要性，这篇综述重点总结了这些通路中的基因表达和非癌细胞DNA变异与铂金疗效的关系。
We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways.
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