大约10%的患者可发展为慢性排斥反应，亦称胆管消失综合征（vanishing bile duct sydrome，VBDS）、慢性同种移植肝排斥反应。其特点是进行性胆汁郁积、胆红素增高、碱性磷酸酶升高，白蛋白和凝血酶原时间可正常。移植肝常增大变硬，但罕见门脉高压。肝病理表现为叶间胆管破坏、进行性纤维增生、汇管区细胞浸润消失、血管内膜纤维化及有时可见泡沫细胞。VBDS几乎不可逆转。需要重新肝移植。
目的：探讨近交系大鼠原位肝移植模型的建立并判断排斥反应发生的强度。
AIM: to establish the orthotopic liver transplantation models in inbred rats and judge the grades of acute rejection.
目的探讨非T细胞来源淋巴细胞活化因子IL 15在大鼠心、肝移植急性排斥反应模型中的作用。
Objective To study the real effect of IL-15, a kind of T lymphocyte activators which were derived from lymphocytes, on the acute rejection process in heart and liver transplantation in rats.
目的：探讨大黄素对大鼠肝移植急性排斥反应的作用机制。
Objective: To investigate the mechanism of Emodin on the role of acute rejection in rat liver transplantation.
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