目前已知唯有肿瘤坏死因子超家族(Tumor necrosis factor Superfamily,TNFSF)的某些成员,可作为细胞外信号,直接启动细胞凋亡途 径杀伤肿瘤细胞,从而具有临床抗肿瘤治疗的潜能。
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3讨 论APRIL是肿瘤坏死因子超家族(tumor necrosis factor, TNF)的一员,1998年首先由Hahne等[13发现并克隆成功。
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是肿瘤坏死因子超家族 tumor necrosis factor superfamily
增殖诱导配体(APRIL)是近年来发现的肿瘤坏死因子(TNF)超家族成员。
A proliferation-induced ligand(APRIL)is a recently found member of tumor necrosis factor (TNF)superfamily.
近年来,肿瘤坏死因子受体超家族成员- OX40 (CD134),作为一共刺激分子对于维持CD 4 + T细胞的活化、增值、存活起到关键性作用。
In recent years, tumor necrosis factor receptor (TNFR) family member-OX40 (CD134), as a key co-stimulatory molecule, involved in maintenance of activation, proliferation, survival of CD4 + t cells.
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