药物效应动力学简称药效学，是研究药物对机体的作用及其规律，阐明药物防治疾病的机制。药物在治疗疾病的同时，也会产生不利于机体的反应(Untoward Reaction or AdverseReaction)，包括副作用(Side Effect )、毒性反应(Toxic Reaction)、变态反应(Allergy Reaction)、继发性反应(Secondary Reaction)后遗效应(Residual Effect )、致畸作用(Teratogenesis) 等。
本文综述了右旋美托咪啶的药理学、药物代谢动力学及其在重症监护病室中的临床应用，包括对谵妄的防治、药物本身的安全性和其特殊的可唤醒镇静效应。
This article reviewed the pharmacology, pharmacokinetics and its application in ICU, including its application in prevention and control of delirium, drug safety and its arousal sedation effects.
结论：中药药效决定于药物动力学参数及效应系数。
Conclusion: The effects of Chinese materia medica were all controlled by pharmacokinetic and pharmacodynamic coefficient.
体外释放第一天呈突释效应，而后药物释放基本符合零级动力学过程。
The pattern of drug release for 30 days in vitro fitted to zero order release plot, with an initial burst effect at the first day.
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