酪氨酸激酶(tyrosine kinase,TK),一种酪氨酸特异性蛋白激酶。NTP(往往是ATP)可作用于蛋白的酪氨酸残基并使其磷酸化,引起其构象改变。
...口服脾酪氨酸激酶抑制剂治疗类风湿关节炎 摘要 背景 脾酪氨酸激酶(Syk)是一种免疫信号的重要调节剂。这个 2 期研究的目的是评价应用于患有 活动性类风湿样关节炎的患者的 R788(一种口服 Syk 的抑制剂...
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酪氨酸激酶抑制剂 tyrosine-kinase inhibitor ; TKI ; tyrosine kinase inhibitor ; EGFR-TKI
受体酪氨酸激酶 receptor tyrosine kinase ; RTK ; MUSK ; receptor
蛋白酪氨酸激酶 PTK ; protein tyrosine kinase ; Jak PTKs ; Protein tyrosinase
布鲁顿酪氨酸激酶 BTK ; Bruton's tyrosine kinase
原癌基因酪氨酸激酶 MERTK
内皮细胞酪氨酸激酶 TEK
酪氨酸激酶受体 receptor tyrosine kinase ; tyrosine kinase receptor ; RTK ; kinase tyrosine insert domain receptor
脾酪氨酸激酶 Spleen tyrosine kinase ; SYK
酪氨酸激酶B TRKB ; tyrosine kinase
目的:对近年来酪氨酸激酶抑制剂的研究进展作以综述。
Objective: to review the progress in the research of tyrosine kinase inhibitors in recent years.
PDGF受体酪氨酸激酶抑制剂在胰腺癌中是否有作用? ?
Is PDGF tyrosine kinase inhibitor effective in pancreatic cancer?
中国的非小细胞肺癌病人中吉非替尼敏感的表皮生长因子受体酪氨酸激酶区域的突变。
Gefitinib-sensitive mutations of the epidermal growth factor receptor tyrosine kinase domain in chinese patients with non-small cell lung cancer.
What a kinase enzyme does is that it recognizes this protein, and for example, the tyrosine that's on the protein.
激酶能够识别这类蛋白,例如,包含酪氨酸的蛋白
Another family is receptor tyrosine kinases, I'll show another picture in a moment that tells you more about what a kinase is, but a kinase is basically an enzyme that can add a phosphorous to another molecule.
另一类是酪氨酸激酶受体,马上我给你们看另一张图,这张图会更详细地告诉你们激酶是什么,激酶是一种能够,向其他分子上添加磷酸基团的酶
In this case, a receptor tyrosine kinase is a receptor molecule that binds a ligand at its surface outside the cell and initiates this enzyme activity - this kinase activity - and causes phosphorylation of another molecule.
在这个例子中,酪氨酸激酶受体可以,在细胞表面区域与配体结合,从而激发出,激酶的活性,使其能够磷酸化另一类分子
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