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In essence, I believe this was not a failure of the drug or the mechanism but a failure of us as investigators to make sure we had sufficient disease in our population upon which to test our hypothesis--somewhat akin to trying to show one antibiotic is better than another or even a placebo, but selecting a population with no infection!
FORBES: Experts Speak On Vytorin Study
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Vilayanur Ramachandran, a researcher at the University of California, San Diego, thinks he may have found that mechanism: a failure of what are known as mirror neurons.
ECONOMIST: Dealing with people changes our minds
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Anyone quick to dismiss this potential problem need only think back on our humbling recent experiences with ICD failures to recognize that the late manifestation of an unanticipated failure mechanism is a fact of reality in cardiac rhythm devices.
FORBES: New ICD Lead Technology Creates New Set of Problems: A Perspective From One Electrophysiologist