Inhibition of poly (ADP-ribose) polymerase has preventive and therapeutic effects on the treatment of shock and ischemia-reperfusion injury.

抑制聚腺苷二磷酸核糖聚合酶对休克和缺血再灌注损伤有良好的防治作用。

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Objective: To observe the expression of poly (ADP-ribose) polymerase (PARP) in focal cerebral ischemia with reperfusion injury and explore the role of PARP in apoptosis.

目的观察多聚ADP 核糖聚合酶（PARP）在脑缺血再灌流损伤中的表达，探讨PARP在细胞凋亡中的作用。

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ADP (adensine diphosphate) A nucleotide consisting of adenine and ribose with two phosphate groups attached. The second phosphate is attached to the first by a high-energy bond.

腺（嘌呤核）苷二磷酸：一种由腺嘌呤和核糖再加上两个磷酸组成的核苷酸。其中第二个磷酸以高能键与第一个磷酸结合。

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By blocking these errant molecules, D-serine and poly ADP-ribose polymerase (PARP), researchers may be able to stop brain cells from dying while avoiding the toxic side effects that have plagued previous experimental treatments.

FORBES: Repairing The Brain

By blocking these errant molecules, called D-serine and poly ADP-ribose polymerase, known as PARP, researchers may be able to stop brain cells from dying, while avoiding the toxic side effects that have plagued previous experimental treatments.

FORBES: Repairing The Brain

Gleason also cites a new class of drugs known as PARP (poly ADP-ribose polymerase) inhibitors, which appear to be highly effective in treating breast cancer patients with certain mutations, and finally the sale of new products that could earn new markets.

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