The analgesic activity was evaluated with acetic acid-induced writhing in mice, the compound was inject hypodermically at a dose of 30mg/kg or administered orally at a dose of 40mg/kg.
在醋酸扭体小鼠模型上,对化合物的镇痛活性进行了评价,在40mg/kg的剂量灌胃或30mg/kg皮下注射给药,多数目标化合物具有不同程度的镇痛活性。
参考来源 - 胍丁胺衍生物的设计合成及生物活性研究In the early-1960s Belgian Janssen et al,reported the new potent analgesic fentanyl for the first time.
20世纪60年代初比利时人Janssen首次报道了新型强效镇痛药芬太尼。
参考来源 - 羟甲芬太尼中间体的合成研究·2,447,543篇论文数据,部分数据来源于NoteExpress
ADJ An analgesic drug reduces the effect of pain. 镇痛药 [正式] [usu ADJ n]
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