We need to settle this once and for all.

我们需要把这事一次解决。

《牛津词典》

All that was needed was one final push, and the enemy would be vanquished once and for all.

只需要最后一次挺进，敌军就将被彻底击败。

《柯林斯英汉双解大词典》

I need to have it out with her once and for all.

我有必要跟她公开彻底地把话说清楚。

《牛津词典》

You just need to remember what's happening to z effective, which really tells us what's happening with all the trends, and once you know z effective, you can figure out, for example, what direction the atomic radius should be going into.

你只需要记住有效核电量的规律，实际上它会告诉我们所有的规律，只要你知道了有效核电量的规律，你就可以判断，比如，原子半径会向着哪个方向发展。

麻省理工公开课 - 化学原理课程节选

First, the Treaty declared that the individual sovereign state would henceforth become the highest level of authority; you might say, putting an end once and for all " to the universalist claims of the Holy Roman Empire.

第一，条约宣称,各个主权国家,都因此而成为各自国家里最高的权力;,永远终结了,普遍意义上的“神圣罗马帝国。

耶鲁公开课 - 政治哲学导论课程节选

Maybe this continuing lack of care for the planet and its people will one day become the reason we leave Earth for once and for all.

BBC: Viewpoint: Should we send humans to Mars?

Gov. Scott Walker is correct to try and corral the issue once and for all.

FORBES: Magazine Article

It could happen again, but Congress also could radically simplify the personal income tax and eradicate earmarks for once and for all.

FORBES: Who Wants To Bet On 2% Inflation?