Recently some new medicines as anti-TNF bodies and T cell directed agents are used in treatment.

近年来国际上对其治疗的研究已主要集中在分子水平上，如抗肿瘤坏死因子（ TNF） 抗体， T细胞靶向药物等。

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Other risk factors were age, the first year of anti-TNF mAb treatment, and being born in an endemic area.

其他的危险因素有年龄、抗TNF单抗治疗第一年及出生在结核流行区。

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Drugs recommended to be stopped before pregnancy include methotrexate and leflunomide, plus the biologics: anti-TNF agents, rituximab and abatacept.

怀孕前应终止使用的药物包括甲氨蝶呤、来氟米特和一些生物制剂包括抗肿瘤坏死因子制剂、利妥昔单抗和阿巴西普。

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In 2008, NICE said patients would not be able to try a second anti-TNF if their first attempt at anti-TNF therapy failed.

BBC: More arthritis drugs to be made available on the NHS

Is simply making an orally available anti-TNF or anti-IL17 interesting enough?

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In March this year, NICE said adalimumab (Humira), etanercept (Enbrel) and infliximab (Remicade) could only be used in the context of research, even for those patients who had failed on one anti-TNF.

BBC: More arthritis drugs to be made available on the NHS