Conclusion: Subclincal dosage of antidepressant is an effective and safe drug for treatment of refractory IBS.

结论：小剂量抗抑郁药是治疗难治性结肠易激综合征的安全和有效的药物。

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To get to your question, the antidepressant potential of ketamine was discovered serendipitously in patients receiving the drug for the treatment of complex regional pain syndrome, or CRPS, a miserable condition characterized by severe pain, swelling and changes in the skin.

CNN: Is it safe to use ketamine as a pain drug?