世界华人消化杂志 Key Words: LNAzyme; Hepatitis C virus; Hepatitis C; Antisense oligonucleotide; Gene therapy [gap=749]关键词: 锁核酸核酶; 丙型肝炎病毒; 丙型肝炎; 反义核酸; 基因治疗
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...中心 关键词 :NMDA受体;反义寡聚核苷酸;免疫组织化学;海马;大鼠 [gap=1020]Key words:NMDA receptor;antisense oligonucleotide;immunohistochemistry;hippocampus;rat ...
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反义寡核苷酸 反义寡核苷酸 ( antisense oligonucleotide )通常指实行了某些化学修饰的短链核酸(约15-25个核苷酸组成),它的碱基依次摆列与特定的靶标RNA序列互补,进来细胞后可遵循Wa...
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ClC-3 antisense oligonucleotide 反义ClC
VEGF antisense oligonucleotide VEGF反义核酸
antisense oligonucleotide ASODN 反义寡核苷酸
antisense oligonucleotide to NR2B 寡核苷酸 ; 反义寡核苷酸
Naphthyl imide-conjugated antisense oligonucleotide 反义寡核苷酸
antisense oligonucleotide of miRNA 的反义寡核苷酸
antisense oligonucleotide drug 反义药物
clc- antisense oligonucleotide 反义clc
wt antisense oligonucleotide wt1反义寡核苷酸
Conclusion: 1. Antisense oligonucleotide targeting survivin can downregulate the protein expression of survivin.
结果:1、Survivin 蛋白在 K562 细胞中呈高表达,转染反义寡核苷酸后 survivin 蛋白表达下调,而无义组及脂质体组无明显变化。
参考来源 - Survivin反义寡核苷酸联合足叶乙甙诱导K562细胞凋亡的实验研究The principle of this technology is the sequence-specific binding of an antisense oligonucleotide (ASOs) to target mRNA, thereby preventing gene translation.
其原理是反义核苷酸能与特定序列互补目标mRNA结合,从而阻止了目标基因表达。
参考来源 - 磁性纳米粒子—反义核苷酸复合物诱导HL·2,447,543篇论文数据,部分数据来源于NoteExpress
Phase II trials with an antisense oligonucleotide against HSP-27 in CRPC are underway.
以HSP-27为靶点的反义寡核甘酸正处于第二期临床试验中。
Objective: to screen the high performance, specific and nontoxic anti HBV antisense oligonucleotide fragment.
目的:筛选出高效特异而无毒的抗hbv反义寡核苷酸片段。
CONCLUSION: EAAC1 antisense oligonucleotide has the neuroprotective effect against acute cerebral ischemia injury.
结论:EAAC 1反义寡核苷酸对急性脑缺血损伤有神经保护作用。
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