The B-cell receptor also represents an important target for patients with B-cell malignancies.

对于B细胞淋巴瘤患者，B细胞受体也代表着一个很重要的药物标靶。

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Receptor tyrosine kinase-like orphan receptor-1 (ROR1) is expressed on sub-populations of B-cell malignancies and solid tumors, but not by healthy B cells or normal postpartum tissues.

受体酪氨酸激酶样孤儿受体1（ROR1）是在B-细胞恶性肿瘤和实体瘤亚群上表达的，但不在健康B细胞或正常产后组织中表达。

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Furthermore, recent data suggests that IRAK4 inhibition synergizes with inhibition of other B-cell receptor signaling pathways, like BTK ( here).

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