Although he's done wrong, you shouldn't become estranged from him.

尽管他犯了错，你也不该疏远他。

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One of the side effects of chasing happiness is you become estranged from yourself.

追逐幸福的其中一个副作用就是你变得和自己疏离。

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People also indicated that the pets may become estranged with your family if you spend your time on getting along with them.

他们这样做是可以理解的，因为宠物可以在他们孤单的时候陪伴他们，他们可以诉说他们的心事和烦恼，人们也可以和宠物一起玩耍。

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Not only have we become hypersensitive to whatever sounds remain - we've also become estranged from the people who make them.

BBC: The dark side of silence

Not particularly smart, not especially articulate, and an emotional wreck, Jeremy Renner's Aaron Cross shows what happens to even the most dedicated federal employees when they are mollycoddled and pampered to the point that they become estranged from the private sector.

WSJ: Joe Queenan on Big Government and The Bourne Legacy | Moving Targets

It's clear by now that Tamerlan felt estranged from American society and had become a devout Muslim before he returned to Dagestan.

CNN: Boston bombing suspects: The Dagestan connection