...产生腹痛， 水电解质紊乱等不良反应，长期使用可丧失蛋白质而 软弱无力，因损害直肠肌间神经丛而形成导泻的结肠(cathartic colon)，此类制剂含有 蒽醌，长期摄取后在结肠黏膜下有黑色素沉积，形成所谓的 结肠黑变病，为一种良性和可恢复的病变。
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Results The frequency and amplitude of slow wave in vivo of rats with cathartic colon was decreased markedly.
结果“泻剂结肠”大鼠的结肠慢波频率减慢，振幅降低；
Methods the model of rat with "cathartic colon" was established, and the changes of colonic electromyography of the rat was examined.
方法建立大鼠“泻剂结肠”模型，并测定其结肠的肌电生理活动变化。
Methods: Set up mouse model of cathartic colon, and measure intestine transmission function by detecting activated charcoal moving in the intestine.
方法：采用大鼠泻剂结肠模型，采用活性炭悬液推进法测定肠道传输功能。
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