If GH or IGF deficiency is acquired, clinical signs and symptoms appear at a later age.

如果生长激素缺乏或胰岛素样生长因子被收购，临床症状和体征出现在较晚的年龄。

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Can clinical signs and symptoms reliably substitute for guidance from expensive and demanding laboratory tests?

临床体征和症状能否可靠地取代昂贵和苛求的实验室检测提供的指导？

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Clinical signs and symptoms of PE are often nonspecific, so imaging has played an important role in the diagnosis.

由于临床症状和体征无特异性，影像诊断起了重要的作用。

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First, of course, what are the clinical signs and symptoms of these diseases because few of us have ever seen cases?

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