The effects of reaction temperature and reaction time on the yield of 3,8-bis-(1-hydroxy-ethyl) deuteroporphyrin dimethyl ester(Ⅱ) were studied. The conditions of esterification reaction were modified.
考察了血红素与溴化氢-冰醋酸饱和溶液反应过程中温度和时间对3,8双--(1羟-基乙基)次卟啉二甲酯(Ⅲ)产率的影响;改进了酯化反应的实验条件;选用了廉价易得、选择性较好的羟基选择性氧化剂。
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