OBJECTIVE We investigated whether the antiproteinuric effect of the direct renin inhibitor aliskiren is comparable to that of irbesartan and the effect of the combination.

目的我们研究直接肾素抑制剂阿利吉仑的抗蛋白尿作用是否与依贝沙坦相当及两者联合的效果。

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Novartis announced today the early termination of the ALTITUDE trial, which was testing the effect of the direct renin inhibitor aliskiren (Rasilez, Tekturna) in type 2 diabetics at high risk for cardiovascular and renal events.

FORBES: ALTITUDE Study of Aliskiren Terminated Early by Novartis