Objective: to investigate the effects of the expression of exogenous brain derived neurotrophic factors (BDNF) on injured spinal cord following in vivo adenoviral gene transfer to the cord.
目的：研究腺病毒介导的脑源性神经营养因子(BDNF)基因在大鼠损伤脊髓内的表达规律，观察外源性BD NF对损伤脊髓的作用。
But it is difficult for exogenous gene to enter brain because of the presence of the blood-brain barrier (BBB). This is the main obstacle for gene transfer therapy in central nervous system.
但血脑屏障的存在却使外源性基因难以进入脑内，是中枢神经系统转基因治疗的主要障碍。
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