ObjectiveTo establish and research the rat model of refractory epilepsy and investigate the rule of P-glycoprotein expression to make the mechanism of drug resistance clear.
目的建立大鼠难治性癫痫模型并观察其特点及研究多药物耐药蛋白P-糖蛋白表达规律，探讨癫痫耐药机制。
Phenylbutyrate induced P-glycoprotein and BCRP expression and the efflux of drugs as determined with labeled substrates.
苯丁酸诱导P糖蛋白和BCRP的表达和药物的外向通量由标记底物来决定。
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