Strong feelings of worthlessness or guilt. You harshly criticize yourself for perceived faults and mistakes.

强烈的无用感或负罪感。你会很严厉地谴责自己的错误和失败。

youdao

Symptoms of depression can include feelings of sadness, anxiety, emptiness, hopelessness, guilt, worthlessness or helplessness. Irritability and restlessness are also common symptoms of depression.

抑郁症的症状包括悲伤、焦虑、空虚、绝望、内疚、无助，烦躁和不安也是抑郁症的常见症状。

youdao

When they are depressed however they feel low, are often tired and might have sleep problems, feelings of worthlessness and guilt.

BBC: NEWS | Health | Call for mental disorder checks