Strong feelings of worthlessness or guilt. You harshly criticize yourself for perceived faults and mistakes.

强烈的无用感或负罪感。你会很严厉地谴责自己的错误和失败。

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Feelings of guilt, worthlessness, or helplessness.

负罪感，价值感缺失或无助感。

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Symptoms of depression can include feelings of sadness, anxiety, emptiness, hopelessness, guilt, worthlessness or helplessness. Irritability and restlessness are also common symptoms of depression.

抑郁症的症状包括悲伤、焦虑、空虚、绝望、内疚、无助，烦躁和不安也是抑郁症的常见症状。

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For instance, there may be feelings of worthlessness, loneliness, panic, anger, guilt, rejection, self-hatred or confused sexuality.

CNN: Self-injury/cutting

When they are depressed however they feel low, are often tired and might have sleep problems, feelings of worthlessness and guilt.

BBC: NEWS | Health | Call for mental disorder checks

Her family said there was nothing to suggest she was unhappy, but a police investigation of her computer revealed she suffered "misplaced" and "unfathomable" feelings of low self-esteem and worthlessness, the inquest was told.

BBC: Teenager Isobel Narayan bought suicide drugs online