The present invention relates to hydroxamic acid derivatives that are inhibitors of histone deacetylase (HDAC).

本发明涉及作为组蛋白脱乙酰基酶（HDAC）抑制剂的异羟肟酸衍 生物。

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HDAC and histone deacetylase inhibitors (HDI) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.

组蛋白脱乙酰基酶与组蛋白脱乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控，影响特定基因的表达，改变细胞周期的进程。

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Scientists then tested a class of drugs called histone deacetylase, or HDAC, inhibitors on the mice.

BBC: NEWS | Health | Scientists 'reverse' memory loss