...胞 印记基因 运动神经元 分化 维甲酸 音猬因子 [gap=1115]Keywords】: parthenogenetic embryonic stem cells,imprinted genes,motor neurons,differentiation,Tretinoin (RA),Sonic hedgehog (Shh) ..
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The present study provided the evidence that maternal diabetes(low serum insulin) alters the expression of imprinted genes, and affects fetal development.
结果显示:小鼠早期胚胎发育环境中胰岛素水平的降低会使胚胎印迹基因Igf2 mRNA表达水平下降,从而阻碍胚胎的生长发育。
参考来源 - 胰岛素对小鼠早期胚胎印迹基因Igf2和H19 mRNA表达的影响·2,447,543篇论文数据，部分数据来源于NoteExpress
These imprinted genes usually result in a balanced, healthy brain, but when the process goes awry, neurological disorders can result.
这些印迹基因往往形成一个平衡的、健康的大脑，但当这个过程出错，就会造成神经系统疾病。
Paternally imprinted genes may have particularly free rein in males, Kono's team reasoned, and may govern traits such as living fast and dying young.
Kono领导的团队推测：带有父亲印记的基因可能对男性有特别自由的控制，从而使之短寿、早逝。
This phenomenon is mostly seen in imprinted genes and X-chromosome inactivation where DNA methylation of promoter regions leads to repression of gene expression.
这种现象主要在印迹基因和X染色体失活区域看到，这些区域中的启动子区的DNA甲基化导致了基因表达的抑制。
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